Anti-aging mechanism of different age donor-matched adipose-derived stem cells.

ABSTRACT:

Background

Adipose-derived stem cells (ASCs) have anti-aging and anti-obesity effects in aged animals, but the underlying molecular mechanism remains unknown.

Methods

In the present study, we evaluated the in vivo transplantation effects of different age donor-matched ASCs on natural aging and leptin knockout mice (ob^-/ob^- mice). The multi-omics expression profiles of young and aged mouse donor-derived ASCs were also analyzed.

Results

The results revealed that ASCs from young donors induced weight and abdominal fat loss for older recipients but not for young or ob^-/ob^-mice. The young and aged mouse donor ASCs displayed significant phenotypic differences, contributing to the distinguished weight loss and anti-aging effects in

SUBMITTER: Wang T 

PROVIDER: S-EPMC10394785 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature