Integrative analysis illustrates the role of PCDH7 in lung cancer development, cisplatin resistance, and immunotherapy resistance: an underlying target.

ABSTRACT: Background: Cisplatin resistance is a common clinical problem in lung cancer. However, the underlying mechanisms have not yet been fully elucidated, highlighting the importance of searching for biological targets. Methods: Bioinformatics analysis is completed through downloaded public data (GSE21656, GSE108214, and TCGA) and specific R packages. The evaluation of cell proliferation ability is completed through CCK8 assay, colony formation, and EdU assay. The evaluation of cell invasion and migration ability is completed through transwell and wound-healing assays. In addition, we evaluated cell cisplatin sensitivity by calculating IC₅₀. Results: Here, we found that PCDH7 may be involved in cisplatin resistance in lung cancer through public database analysis (

SUBMITTER: Li H 

PROVIDER: S-EPMC10394841 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature