Beneficial effects of alpha-1 antitrypsin therapy in a mouse model of colitis-associated colon cancer.

ABSTRACT:

Background

It is widely accepted that chronic inflammatory bowel diseases significantly higher a risk for colorectal cancer development. Among different types of treatments for patients with colon cancer, novel protein-based therapeutic strategies are considered.

Aim

To explore the effect of human plasma alpha-1 antitrypsin (AAT) protein in the chemically induced mouse model of colorectal cancer.

Methods

BALB/c mice with azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated colorectal cancer (CAC), we intraperitoneally treated with commercial preparation of human plasma AAT (4 mg per mouse). Effects of this therapy were evaluated histologically, and by immunohistochemical and gene expression assays.

Results

When compared with non-treated cont

SUBMITTER: Al-Omari M 

PROVIDER: S-EPMC10394932 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature