Common antibiotics, azithromycin and amoxicillin, affect gut metagenomics within a household.

ABSTRACT:

Background

The microbiome of the human gut serves a role in a number of physiological processes, but can be altered through effects of age, diet, and disturbances such as antibiotics. Several studies have demonstrated that commonly used antibiotics can have sustained impacts on the diversity and the composition of the gut microbiome. The impact of the two most overused antibiotics, azithromycin, and amoxicillin, in the human microbiome has not been thoroughly described. In this study, we recruited a group of individuals and unrelated controls to decipher the effects of the commonly used antibiotics amoxicillin and azithromycin on their gut microbiomes.

Results

We characterized the gut microbiomes by metagenomic sequencing followed by characterization of the resulting microbi

SUBMITTER: Chopyk J 

PROVIDER: S-EPMC10394940 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature