Proteomic profile of extracellular vesicles in maternal plasma of women with fetal death.

ABSTRACT:

Objectives

Fetal death is a complication of pregnancy caused by multiple etiologies rather than being the end-result of a single disease process. Many soluble analytes in the maternal circulation, such as hormones and cytokines, have been implicated in its pathophysiology. However, changes in the protein content of extracellular vesicles (EVs), which could provide additional insight into the disease pathways of this obstetrical syndrome, have not been examined. This study aimed to characterize the proteomic profile of EVs in the plasma of pregnant women who experienced fetal death and to evaluate whether such a profile reflected the pathophysiological mechanisms of this obstetrical complication. Moreover, the proteomic results were compared to and integrated with those obtained fro

SUBMITTER: Gallo DM 

PROVIDER: S-EPMC10395052 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature