DNA methylation profiling in Trisomy 21 females with and without breast cancer.

ABSTRACT:

Background

Down Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer however they are at higher risk of developing acute myeloid leukemia and acute lymphoblastic leukemia.

Methods

In this study, we investigated DNA methylation signatures and epigenetic aging in DS individuals with and without breast cancer. We analyzed DNA methylation patterns in Trisomy 21 (T21) individuals without breast cancer (T21-BCF) and DS individuals with breast cancer (T21-BC), using the Infinium Methylation EPIC BeadChip array.

Results

Our results revealed several differentially methylated sites and regions in th

SUBMITTER: Bejaoui Y 

PROVIDER: S-EPMC10395079 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature