Microenvironmental and cell intrinsic factors governing human cDC2 differentiation and monocyte reprogramming.

ABSTRACT: cDC2s occur abundantly in peripheral tissues and arise from circulating blood cDC2s. However, the factors governing cDC2 differentiation in tissues, especially under inflammatory conditions, remained poorly defined. We here found that psoriatic cDC2s express the efferocytosis receptor Axl and exhibit a bone morphogenetic protein (BMP) and p38MAPK signaling signature. BMP7, strongly expressed within the lesional psoriatic epidermis, cooperates with canonical TGF-β1 signaling for inducing Axl⁺cDC2s from blood cDC2s in vitro. Moreover, downstream induced p38MAPK promotes Axl⁺cDC2s at the expense of Axl⁺CD207⁺ Langerhans cell differentiation from blood cDC2s. BMP7 supplementation allowed to model cDC2 generation and their further differentiati

SUBMITTER: Lang M 

PROVIDER: S-EPMC10395083 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature