A membrane intercalating metal-free conjugated organic photosensitizer for bacterial photodynamic inactivation.

ABSTRACT: Photodynamic inhibition (PDI) of bacteria represents a powerful strategy for dealing with multidrug-resistant pathogens and infections, as it exhibits minimal development of antibiotic resistance. The PDI action stems from the generation of a triplet state in the photosensitizer (PS), which subsequently transfers energy or electrons to molecular oxygen, resulting in the formation of reactive oxygen species (ROS). These ROS are then able to damage cells, eventually causing bacterial eradication. Enhancing the efficacy of PDI includes the introduction of heavy atoms to augment triplet generation in the PS, as well as membrane intercalation to circumvent the problem of the short lifetime of ROS. However, the former approach can pose safety and environmental concerns, while achieving stable me

SUBMITTER: Magni A 

PROVIDER: S-EPMC10395270 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature