Comorbidity and polypharmacy impact neurobehavioral symptoms and symptom validity failure among post-9/11 veterans with mild traumatic brain injury.

ABSTRACT:

Objective

The study aimed to examine the association between post-concussive comorbidity burdens [post-traumatic stress disorder (PTSD), depression, and/or headache] and central nervous system (CNS) polypharmacy (five or more concurrent medications) with reported neurobehavioral symptoms and symptom validity screening among post-9/11 veterans with a history of mild traumatic brain injury (mTBI).

Setting

Administrative medical record data from the Department of Veterans Affairs (VA) were used in the study.

Participants

Post-9/11 veterans with mTBI and at least 2 years of VA care between 2001 and 2019 who had completed the comprehensive traumatic brain injury evaluation (CTBIE) were included in the study.

Design

Retrospective cross-sectional design was used in th

SUBMITTER: Swan AA 

PROVIDER: S-EPMC10395329 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature