Identification and characterization of putative biomarkers and therapeutic axis in Glioblastoma multiforme microenvironment.

ABSTRACT: Non-cellular secretory components, including chemokines, cytokines, and growth factors in the tumor microenvironment, are often dysregulated, impacting tumorigenesis in Glioblastoma multiforme (GBM) microenvironment, where the prognostic significance of the current treatment remains unsatisfactory. Recent studies have demonstrated the potential of post-translational modifications (PTM) and their respective enzymes, such as acetylation and ubiquitination in GBM etiology through modulating signaling events. However, the relationship between non-cellular secretory components and post-translational modifications will create a research void in GBM therapeutics. Therefore, we aim to bridge the gap between non-cellular secretory components and PTM modifications through machine learning and comput

SUBMITTER: Kumari S 

PROVIDER: S-EPMC10395518 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature