Prescription of oxycodone versus codeine after childbirth and risk of persistent opioid use: a population-based cohort study.

ABSTRACT:

Background

Oxycodone is increasingly prescribed for postpartum analgesia in lieu of codeine owing to concerns regarding the neonatal safety of codeine during lactation. We examined whether initiation of oxycodone after delivery was associated with an increased risk of persistent opioid use relative to initiation of codeine.

Methods

We conducted a population-based cohort study of people who filled a prescription for either codeine or oxycodone within 7 days of discharge from hospital after delivery between Sept. 1, 2012, and June 30, 2020. The primary outcome was persistent opioid use, defined as 1 or more additional prescriptions for an opioid within 90 days of the first postpartum prescription and 1 or more additional prescriptions in the 91 to 365 days thereafter. We used

SUBMITTER: Zipursky JS 

PROVIDER: S-EPMC10395796 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature