Exploring Endotypes in Chronic Rhinosinusitis (ExpRess): Protocol for a cohort study.

ABSTRACT:

Background

Chronic Rhinosinusitis (CRS) affects approximately 1 in 10 UK adults and impacts quality of life quality of life significantly. Response to treatment may be driven by individual CRS endotypes and therefore work to delineate biomarker clusters that may separate responders from non-responders is needed. The ongoing MACRO three-arm parallel-group trial randomises adult CRS patients to endoscopic sinus surgery, macrolide therapy or placebo.

Aim

This study aims to correlate CRS endotypes with clinical parameters from the ongoing MACRO trial, including olfactory function and outcomes in terms of response to treatment using core biomarkers sets.

Methods

Adult CRS patients enrolled into the MACRO trial will be recruited from participating UK otorhinolaryngology dep

SUBMITTER: Gokani SA 

PROVIDER: S-EPMC10395813 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature