Theoretical efficiency limits and speed-efficiency trade-off in myosin motors.

ABSTRACT: Muscle myosin is a non-processive molecular motor that generates mechanical work when cooperating in large ensembles. During its cyle, each individual motor keeps attaching and detaching from the actin filament. The random nature of attachment and detachment inevitably leads to losses and imposes theoretical limits on the energetic efficiency. Here, we numerically determine the theoretical efficiency limit of a classical myosin model with a given number of mechano-chemical states. All parameters that are not bounded by physical limits (like rate limiting steps) are determined by numerical efficiency optimization. We show that the efficiency is limited by the number of states, the stiffness and the rate-limiting kinetic steps. There is a trade-off between speed and efficiency. Slow motors a

SUBMITTER: Vilfan A 

PROVIDER: S-EPMC10395908 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature