Chagas disease is related to structural changes of the gut microbiota in adults with chronic infection (TRIPOBIOME Study).

ABSTRACT:

Background

The implications of the gut microbial communities in the immune response against parasites and gut motility could explain the differences in clinical manifestations and treatment responses found in patients with chronic Chagas disease.

Methodology/principal findings

In this pilot prospective cross-sectional study, we included 80 participants: 29 with indeterminate CD (ICD), 16 with cardiac CD (CCD), 15 with digestive CD (DCD), and 20 controls without CD. Stool was collected at the baseline visit and faecal microbial community structure DNA was analyzed by whole genome sequencing. We also performed a comprehensive dietary analysis. Ninety per cent (72/80) of subjects were of Bolivian origin with a median age of 47 years (IQR 39-54) and 48.3% (29/60) had received be

SUBMITTER: Perez-Molina JA 

PROVIDER: S-EPMC10395948 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature