Cross-scale tracing of nanoparticles and tumors at the single-cell level using the whole-lung atlas.

ABSTRACT: Currently, the effectiveness of oncotherapy is limited by tumor heterogeneities, which presents a huge challenge for the development of nanotargeted drug delivery systems (DDSs). Therefore, it is important to resolve the spatiotemporal interactions between tumors and nanoparticles. However, targeting evaluation has been limited by particle visualization due to the gap between whole-organ scale and subcellular precision. Here, a high-precision three-dimensional (3D) visualization of tumor structure based on the micro-optical sectioning tomography (MOST) system and fluorescence MOST (fMOST) system is presented to clarify 3D spatial distribution of nanoparticles within the tumor. We demonstrate that through the MOST/fMOST system, it is possible to reveal multidimensional and cross-scale corre

SUBMITTER: Cao Z 

PROVIDER: S-EPMC10396308 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature