Control of telomere length in yeast by SUMOylated PCNA and the Elg1 PCNA unloader.

ABSTRACT: Telomeres cap and protect the linear eukaryotic chromosomes. Telomere length is determined by an equilibrium between positive and negative regulators of telomerase activity. A systematic screen for yeast mutants that affect telomere length maintenance in the yeast Saccharomyces cerevisiae revealed that mutations in any of ~500 genes affects telomere length. One of the genes that, when mutated, causes telomere elongation is ELG1, which encodes an unloader of PCNA, the processivity factor for replicative DNA polymerases. PCNA can undergo SUMOylation on two conserved residues, K164 and K127, or ubiquitination at lysine 164. These modifications have already been implicated in genome stability processes. We report that SUMOylated PCNA acts as a signal that positively regulates tel

SUBMITTER: Singh P 

PROVIDER: S-EPMC10396338 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature