Maternal infections and medications in pregnancy: how does self-report compare to medical records in childhood cancer case-control studies?

ABSTRACT:

Background

Studies examining the potential impact of mothers' health during pregnancy on the health of their offspring often rely on self-reported information gathered several years later. To assess the validity of this approach, we analysed data from a national case-control study of childhood cancer (diagnosed <15 years) that collected health information from both interviews and medical records.

Methods

Mothers' interview reports of infections and medications in pregnancy were compared with primary care records. Taking clinical diagnoses and prescriptions as the reference, sensitivity and specificity of maternal recall along with kappa coefficients of agreement were calculated. Differences in the odd ratios estimated using logistic regression for each information source wer

SUBMITTER: Bonaventure A 

PROVIDER: S-EPMC10396422 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature