Exploration of epithelial-mesenchymal transition-related lncRNA signature and drug sensitivity in breast cancer.

ABSTRACT:

Background

Breast cancer (BRCA) has become the most diagnosed cancer worldwide for female and seriously endanger female health. The epithelial-mesenchymal transition (EMT) process is associated with metastasis and drug resistance in BRCA patients. However, the prognostic value of EMT-related lncRNA in BRCA still needs to be revealed. The aim of this study is to construct an EMT-related lncRNA (ERL) signature with accuracy predictive ability for the prognosis of BRCA patients.

Methods

RNA-seq expression data and Clinical characteristics obtained from the TCGA (The Cancer Genome Atlas) were used in the study. First, we identified the EMT-related lncRNA by the Pearson correlation analysis. An EMT-related lncRNAs prognostic risk signature was constructed using univariate Cox reg

SUBMITTER: Li C 

PROVIDER: S-EPMC10396438 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature