Circulating FGF18 is decreased in pleural mesothelioma but not correlated with disease prognosis.

ABSTRACT:

Background

Pleural mesothelioma (PM) is a relatively rare malignancy with limited treatment options and dismal prognosis. We have previously found elevated FGF18 expression in PM tissue specimens compared with normal mesothelium. The objective of the current study was to further explore the role of FGF18 in PM and evaluate its suitability as a circulating biomarker.

Methods

FGF18 mRNA expression was analyzed by real-time PCR in cell lines and in silico in datasets from the Cancer Genome Atlas (TCGA). Cell lines overexpressing FGF18 were generated by retroviral transduction and cell behavior was investigated by clonogenic growth and transwell assays. Plasma was collected from 40 PM patients, six patients with pleural fibrosis, and 40 healthy controls. Circulating FGF18 was me

SUBMITTER: Mosleh B 

PROVIDER: S-EPMC10396789 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature