A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection.

ABSTRACT: Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2 remain asymptomatic^1-4. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance. Here, postulating that variation in the human leukocyte antigen (HLA) loci may underly processes mediating asymptomatic infection, we enrolled 29,947 individuals, for whom high-resolution HLA genotyping data were available, in a smartphone-based study designed to track COVID-19 symptoms and outcomes. Our discovery cohort (n = 1,428) comprised unvaccinated individuals who reported a positive test result for SARS-CoV-2. We tested for association of five HLA loci wit

SUBMITTER: Augusto DG 

PROVIDER: S-EPMC10396966 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature