Total transcriptome analysis of Candida auris planktonic cells exposed to tyrosol.

ABSTRACT: Tyrosol, a secondary metabolite of Candida species, regulates fungal morphogenesis, and its application may represent a novel innovative therapy against emerging multi-resistant fungal superbug such as Candida auris. In the current study, the effects of tyrosol on growth, redox homeostasis, intracellular microelement contents and activities of virulence-related enzymes released by C. auris were examined. To gain further information about the effect of tyrosol exposure, we revealed gene transcriptional changes using total transcriptome sequencing (RNA-Seq). At a concentration of 15 mM, tyrosol significantly decrease the growth of fungal cells within 2 h of its addition (5.6 × 10⁷±1.2 × 10⁷ and 2.5 × 10⁷±0.6 × 10⁷ colony forming unit/mL for control

SUBMITTER: Balla N 

PROVIDER: S-EPMC10397170 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature