Effects of cholesterol-lowering probiotics on non-alcoholic fatty liver disease in FXR gene knockout mice.

ABSTRACT:

Background/aims

Some studies showed that probiotics could improve the composition and structure of gut microbiota. Changes in the gut microbiota may alter bile acid (BAs) composition and kinetics, improving non-alcoholic fatty liver disease (NAFLD). However, it still needs to be clarified how probiotics improve both the metabolism of BAs and NAFLD. This study aimed to reveal the regulatory mechanisms of cholesterol-lowering (CL) probiotics on NAFLD from aspects involved in BA metabolism in FXR gene knockout (FXR^-/-) mice.

Methods

FXR^-/- male mice were randomly divided into three groups based on different interventions for 16 weeks, including normal diet (ND), high-fat diet (HFD), and probiotic intervention in the HFD (HFD+P) group. 16s rDNA sequencing a

SUBMITTER: Yang M 

PROVIDER: S-EPMC10397539 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature