A model for cis-regulation of transcriptional condensates and gene expression by proximal lncRNAs.

ABSTRACT: Long noncoding RNAs (lncRNAs) perform several important functions in cells including cis-regulation of transcription. Barring a few specific cases, the mechanisms underlying transcriptional regulation by lncRNAs remain poorly understood. Transcriptional proteins can form condensates via phase separation at protein-binding loci (BL) on the genome (e.g., enhancers and promoters). lncRNA-coding genes are present at loci in close genomic proximity of these BL and these RNAs can interact with transcriptional proteins via attractive heterotypic interactions mediated by their net charge. Motivated by these observations, we propose that lncRNAs can dynamically regulate transcription in cis via charge-based heterotypic interactions with transcriptional proteins in condensates. To study the conseque

SUBMITTER: Natarajan P 

PROVIDER: S-EPMC10397817 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature