Comparative Risks of Potential Adverse Events Following COVID-19 mRNA Vaccination Among Older US Adults.

ABSTRACT:

Importance

Head-to-head safety comparisons of the mRNA vaccines for SARS-CoV-2 are needed for decision making; however, current evidence generalizes poorly to older adults, lacks sufficient adjustment, and inadequately captures events shortly after vaccination. Additionally, no studies to date have explored potential variation in comparative vaccine safety across subgroups with frailty or an increased risk of adverse events, information that would be useful for tailoring clinical decisions.

Objective

To compare the risk of adverse events between mRNA vaccines for COVID-19 (mRNA-1273 and BNT162b2) overall, by frailty level, and by prior history of the adverse events of interest.

Design, setting, and participants

This retrospective cohort study was conducted between Dec

SUBMITTER: Harris DA 

PROVIDER: S-EPMC10398407 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature