Unknown

Dataset Information

0

Efficacy and safety of latanoprost/timolol fixed combination dosed twice daily compared to once daily in patients with primary open angle glaucoma.


ABSTRACT:

Aim

To evaluate whether latanoprost/timolol fixed combination (LTFC) dosed twice daily may provide further intraocular pressure (IOP) reduction and evaluate the safety profile at this dose.

Methods

This is an open-labeled, randomized, prospective crossover study on fourty primary open angle glaucoma patients. Two weeks of washout period were followed by randomization to either once daily (OD, group A) or twice daily dosing (BD, group B) of LTFC for 4wk. After another 2-week washout period, the patients' treatment dose was crossed-over for another 4wk. IOP reduction alongside ocular and systemic side effects were evaluated.

Results

Mean baseline IOP was 18.57±2.93 and 17.8±3.01 mm Hg before OD and BD dose respectively, (P=0.27). Mean IOP after BD dose was statistically lower (12.49±1.59 mm Hg) compared to OD (13.48±1.81 mm Hg, P=0.017). Although IOP reduction after BD dose was more (5.32±3.24 mm Hg, 29.89%) than after OD dosing (5.04 mm Hg, 27.14%), it did not reach statistical significance (P=0.68). Patients switched from OD to BD (group A) showed mean IOP reduction by 0.69 mm Hg [95% confidence interval (CI): -0.09 to 1.48 mm Hg, P=0.078]; but patients switched from BD to OD (group B) had significantly higher mean IOP by 1.25 mm Hg (95%CI: -2.04 to -0.46 mm Hg, P=0.006). BD dose had more ocular side effects albeit mild.

Conclusion

Mean IOP after LTFC dosed twice daily is statistically lower, with additional mild side effects.

SUBMITTER: Azal AB 

PROVIDER: S-EPMC10398532 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

altmetric image

Publications

Efficacy and safety of latanoprost/timolol fixed combination dosed twice daily compared to once daily in patients with primary open angle glaucoma.

Azal Anis Baidura AB   Hussein Siti Husna SH   Tang Seng Fai SF   Othman Othmaliza O   Din Norshamsiah Md NM  

International journal of ophthalmology 20230818 8


<h4>Aim</h4>To evaluate whether latanoprost/timolol fixed combination (LTFC) dosed twice daily may provide further intraocular pressure (IOP) reduction and evaluate the safety profile at this dose.<h4>Methods</h4>This is an open-labeled, randomized, prospective crossover study on fourty primary open angle glaucoma patients. Two weeks of washout period were followed by randomization to either once daily (OD, group A) or twice daily dosing (BD, group B) of LTFC for 4wk. After another 2-week washou  ...[more]

Similar Datasets

| S-EPMC3259580 | biostudies-literature
| S-EPMC10829799 | biostudies-literature
| S-EPMC4741129 | biostudies-literature
| S-EPMC3175210 | biostudies-literature
| S-EPMC7046276 | biostudies-literature
| S-EPMC4934872 | biostudies-literature
| S-EPMC9800952 | biostudies-literature
| S-EPMC10806046 | biostudies-literature
| S-EPMC3986331 | biostudies-literature
| S-EPMC3578670 | biostudies-literature