Association between genetic predisposition and disease burden of stroke in China: a genetic epidemiological study.

ABSTRACT:

Background

Stroke ranks second worldwide and first in China as a leading cause of death and disability. It has a polygenic architecture and is influenced by environmental and lifestyle factors. However, it remains unknown as to whether and how much the genetic predisposition of stroke is associated with disease burden.

Methods

Allele frequency from the whole genome sequencing data in the Chinese Millionome Database of 141,418 individuals and trait-specific polygenic risk score models were applied to estimate the provincial genetic predisposition to stroke, stroke-related risk factors and stroke-related drug response. Disease burden including mortality, disability-adjusted life years (DALYs), years of life lost(YLLs), years lived with disability (YLDs) and prevalence in China

SUBMITTER: Huang Q 

PROVIDER: S-EPMC10398595 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature