Cyclization of Chalcone Derivatives: Design, Synthesis, In Silico Docking Study, and Biological Evaluation of New Quinazolin-2,4-diones Incorporating Five-, Six-, and Seven-Membered Ring Moieties as Potent Antibacterial Inhibitors.

ABSTRACT: Four novel series of quinazolin-2,4-diones bearing five-, six-, and seven-membered heterocyclic moieties 2-14 (such as pyrazole, oxazole, pyrimidine, and azepines) through the 1,4-phenyl linkage were designed, synthesized, and evaluated in terms of their antibacterial activities. Analytical and spectral techniques (FT-IR, ¹H NMR, ¹³C NMR, and Mass) were utilized for the structural elucidation of all of the synthesized compounds 2-14. Furthermore, the potential antibacterial activity of the thirteen compounds was further evaluated in vitro against two different Gram-negative G^-ve bacterial strains (named Escherichia coli ATCC 25955, Pseudomonas aeruginosa ATCC 10145) and two Gram-positive G^+ve bacte

SUBMITTER: El-Naggar M 

PROVIDER: S-EPMC10398699 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature