Utility and Safety of Backup Insulin Regimens Generated by the Bionic Pancreas: A Randomized Study.

ABSTRACT: The bionic pancreas (BP) is initialized with body weight only and doses insulin autonomously without carbohydrate counting, instead using qualitative meal announcements. In case of device malfunction, the BP generates and continuously updates backup insulin doses for injection or pump users, including long-acting insulin dose, a four-period basal insulin profile, short-acting meal doses, and a glucose correction factor. Following a 13-week trial in type 1 diabetes, participants using the BP (6-83 years) completed 2-4 days, in which they were randomly assigned to their prestudy insulin regimen (N = 147) or to follow BP-provided guidance (N = 148). Glycemic outcomes with BP guidance were similar to those reinstituting their prestudy insulin regimen, with both groups having high

SUBMITTER: Mauras N 

PROVIDER: S-EPMC10398715 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature