Molecular changes underlying decay of sensory responses and enhanced seizure propensity in peritumoral neurons.

ABSTRACT:

Background

Glioblastoma growth impacts on the structure and physiology of peritumoral neuronal networks, altering the activity of pyramidal neurons which drives further tumor progression. It is therefore of paramount importance to identify glioma-induced changes in pyramidal neurons, since they represent a key therapeutic target.

Methods

We longitudinal monitored visual evoked potentials after the orthotopic implant of murine glioma cells into the mouse occipital cortex. With laser microdissection, we analyzed layer II-III pyramidal neurons molecular profile and with local field potentials recordings we evaluated the propensity to seizures in glioma-bearing animals with respect to control mice.

Results

We determine the time course of neuronal dysfunction of glioma-bea

SUBMITTER: Tantillo E 

PROVIDER: S-EPMC10398807 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature