The <i>Tetrahymena bcd1</i> mutant implicates endosome trafficking in ciliate, cortical pattern formation.

ABSTRACT: Ciliates, such as Tetrahymena thermophila, evolved complex mechanisms to determine both the location and dimensions of cortical organelles such as the oral apparatus (OA: involved in phagocytosis), cytoproct (Cyp: for eliminating wastes), and contractile vacuole pores (CVPs: involved in water expulsion). Mutations have been recovered in Tetrahymena that affect both the localization of such organelles along anterior-posterior and circumferential body axes and their dimensions. Here we describe BCD1, a ciliate pattern gene that encodes a conserved Beige-BEACH domain-containing protein a with possible protein kinase A (PKA)-anchoring activity. Similar proteins have been implicated in endosome trafficking and are linked to human Chediak-Higashi syndrome and autism. Mutatio

SUBMITTER: Cole ES 

PROVIDER: S-EPMC10398878 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature