Genetic diversity and natural selection of Plasmodium vivax reticulocyte invasion genes in Ecuador.

ABSTRACT:

Background

Knowledge of the diversity of invasion ligands in malaria parasites in endemic regions is essential to understand how natural selection influences genetic diversity of these ligands and their feasibility as possible targets for future vaccine development. In this study the diversity of four genes for merozoite invasion ligands was studied in Ecuadorian isolates of Plasmodium vivax.

Methods

Eighty-eight samples from P. vivax infected individuals from the Coast and Amazon region of Ecuador were obtained between 2012 and 2015. The merozoite invasion genes pvmsp-1-19, pvdbpII, pvrbp1a-2 and pvama1 were amplified, sequenced, and compared to the Sal-1 strain. Polymorphisms were mapped and genetic relationships between haplotypes were determined.

Results

Only one

SUBMITTER: Nunez A 

PROVIDER: S-EPMC10398936 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature