PAX1 hypomethylation as a prognostic biomarker for radioresistance of cervical cancer.

ABSTRACT:

Background

PAX1 gene methylation plays an important role in the development of cervical cancer. However, its prognostic value after radiotherapy for locally advanced cervical cancer is unknown, so this study aimed to investigate the value of PAX1 gene methylation for predicting the sensitivity of radiotherapy for cervical cancer.

Methods

We selected 125 patients with primary cervical cancer who underwent concurrent chemo-radiotherapy as the study population, quantitative methylation-specific polymerase chain reaction (QMSP) was used for detecting PAX1 methylation status of cervical exfoliated cells. Logistic regression model was used to analyze the risk factors associated with the short-term efficacy and to establish a prediction model of radiotherapy sensitivity based on PA

SUBMITTER: Li X 

PROVIDER: S-EPMC10398938 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature