Human Alzheimer's disease reactive astrocytes exhibit a loss of homeostastic gene expression.

ABSTRACT: Astrocytes are one of the brain's major cell types and are responsible for maintaining neuronal homeostasis via regulating the extracellular environment, providing metabolic support, and modulating synaptic activity. In neurodegenerative diseases, such as Alzheimer's disease, astrocytes can take on a hypertrophic appearance. These reactive astrocytes are canonically associated with increases in cytoskeletal proteins, such as glial fibrillary acidic protein and vimentin. However, the molecular alterations that characterize astrocytes in human disease tissues have not been extensively studied with single cell resolution. Using single nucleus RNA sequencing data from normal, pathologic aging, and Alzheimer's disease brains, we identified the transcriptomic changes associated with reactive ast

SUBMITTER: Dai DL 

PROVIDER: S-EPMC10398957 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature