Association of remnant cholesterol with frailty: findings from observational and Mendelian randomization analyses.

ABSTRACT:

Background

Recent insights suggest that remnant cholesterol (RC) plays a role in cellular senescence, yet its specific contribution to frailty remains indeterminate. Through the integration of observational and mendelian randomization (MR) studies, this research explores the impact of elevated serum RC levels on frailty susceptibility.

Methods

A dual-method approach, combining an observational study with an MR study, was employed to investigate the connection between RC and frailty. The observational study included 11,838 participants from the National Health and Nutrition Examination Survey. Multivariable logistic regression and propensity score matching were employed to control for potential confounders. The non-linear relationship was assessed using restricted cubic splin

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10399004 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature