UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.

ABSTRACT:

Background

Renal interstitial fibrosis is a common pathway for the progressive development of chronic renal diseases (CKD) with different etiology, and is the main pathological basis leading to end-stage renal disease. Although the current research on renal interstitial fibrosis is gradually deepening, the diagnosis and treatment methods are still very lacking. Uncoupling protein 1 (UCP1) is a nuclear encoded protein in mitochondria inner membrane and plays an important role in regulating energy metabolism and mitochondrial homeostasis. However, the biological significance of UCP1 and potential regulatory mechanisms in the development of CKD remain unclear.

Methods

Unilateral ureteral obstruction (UUO) model was used to construct the animal model of renal fibrosis, and TGF-β

SUBMITTER: Xiong W 

PROVIDER: S-EPMC10399010 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature