Real-world effectiveness of repeated intravenous ketamine infusions for treatment-resistant depression in transitional age youth.

ABSTRACT:

Background

Ketamine is an emerging treatment for treatment-resistant depression (TRD) associated with rapid and robust improvements in depressive symptoms and suicidality. However, the efficacy and safety of ketamine in transitional age youth (TAY; age 18-25) populations remains understudied.

Methods

In this retrospective analysis, TAY patients (n = 52) receiving ketamine for TRD were matched for sex, primary diagnosis, baseline depression severity, and treatment resistance with a general adult (GA) sample (age 30-60). Patients received four ketamine infusions over 2 weeks (0.5-0.75 mg/kg over 40 min). The primary outcome was the change in Quick Inventory of Depressive Symptomatology Self-Report 16-item (QIDS-SR16) over time. Secondary outcomes were changes in QIDS-SR

SUBMITTER: Chisamore N 

PROVIDER: S-EPMC10399094 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature