Genomic epidemiology and multilevel genome typing of Bordetella pertussis.

ABSTRACT: Bordetella pertussis causes pertussis (or whooping cough), a severe respiratory infectious disease in infants, although it can be prevented by whole cell and acellular vaccines. The recent pertussis resurgence in industrialised countries is partly attributed to pathogen adaptation to vaccines, while emergence of antimicrobial resistance, specifically to macrolides in China, has become a concern. Surveillance of current circulating and emerging strains is therefore vital to understand the risks they pose to public health. Although the use of genomics-based typing is increasing a genomic nomenclature for this pathogen has not been well established. Here, we implemented the multilevel genome typing (MGT) system for B. pertussis with five levels of resolution, which provide targe

SUBMITTER: Payne M 

PROVIDER: S-EPMC10399484 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature