Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI-trajectories from infancy to 26 years.

ABSTRACT:

Objective

To date, epigenetic studies identified differential DNA methylation (DNAm) related to gestational-body mass index (BMI) in offspring at birth. This study investigated whether the identified DNAm in offspring were also associated with BMI trajectories from infancy to age 26 years.

Methods

Data of 794 participants from Isle of Wight birth cohort in UK were investigated to study association between BMI trajectories and DNAm related to gestational-BMI at birth. Multinominal logistic regression models were applied to test the association between 1090 DNAm sites reported in three prior epigenome-wide association studies and BMI trajectories.

Results

DNAm site cg23089913 (NANOS1) and cg13217064 (SOX14) were associated with early persistent obesity (EP

SUBMITTER: Janjanam VD 

PROVIDER: S-EPMC10399520 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature