Health state utilities associated with hyperphagia: Data for use in cost-utility models.

ABSTRACT:

Objective

Rare genetic diseases of obesity typically present with hyperphagia, a pathologic desire to consume food. Cost-utility models assessing the value of treatments for these rare diseases will require health state utilities representing hyperphagia. This study estimated utilities associated with various hyperphagia severity levels.

Methods

Four health state vignettes were developed using published literature and clinician input to represent various severity levels of hyperphagia. Utilities were estimated for these health states in a time trade-off elicitation study in a UK general population sample.

Results

In total, 215 participants completed interviews (39.5% male; mean age 39.1 years). Mean (SD) utilities were 0.98 (0.02) for no hyperphagia, 0.91 (0.10) for m

SUBMITTER: Howell TA 

PROVIDER: S-EPMC10399521 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature