Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.

ABSTRACT: Down syndrome is the most common chromosomal abnormality in humans. Patients with Down syndrome have hematologic disorders, including mild to moderate thrombocytopenia. In case of Down syndrome, thrombocytopenia is not associated with bleeding, and it remains poorly characterized regarding molecular mechanisms. We investigated the effects of overexpression of Dyrk1A, an important factor contributing to some major Down syndrome phenotypes, on platelet number and bleeding in mice. Mice overexpressing Dyrk1A have a decrease in platelet number by 20%. However, bleeding time was found to be reduced by 50%. The thrombocytopenia and the decreased bleeding time observed were not associated to an abnormal platelet receptors expression, to a defect of platelet activation by ADP, thrombin or convulxi

SUBMITTER: Postic G 

PROVIDER: S-EPMC10399536 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature