Molecular characterization of multidrug resistant Acinetobacter baumannii clinical isolates from Alexandria, Egypt.

ABSTRACT: Carbapenem resistant Acinetobacter baumannii is a major global concern, especially in countries of the Middle East and North Africa, where the antibiotic resistance rates are on the rise. The aim of this study was to study the genomic characteristics and antimicrobial susceptibility profile of thirty-six multidrug resistant A. baumannii clinical isolates obtained in hospitals from Alexandria, Egypt. Antibiotic resistance rates were estimated by determination of Minimum Inhibitory Concentrations. Carbapenemase genes, other antibiotic resistance genes and virulence factors were then screened by the use of Whole Genome Sequencing. Isolates were also subjected to Multi Locus Sequence Typing (MLST) using the Pasteur Scheme and to core genome MLST to study their clonal relatedness.

SUBMITTER: Sanchez-Urtaza S 

PROVIDER: S-EPMC10399577 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature