Study of Ceramide-Flavone Analogs Showing Self-Fluorescence and Anti-Proliferation Activities.

ABSTRACT:

Background

Many current anti-cancer drugs used to treat breast cancer mediate tumor cell death through the induction of apoptosis. Cancer cells, however, often acquire multidrug-resistance following prolonged exposure to chemotherapeutics. Consequently, molecular pathways involved in tumor cell proliferation have become potential targets for pharmacological intervention. Ceramides are tumor suppressor lipids naturally found in the cell membrane, and are central molecules in the sphingolipid signalling pathway.

Methods

Our lab has targeted the ceramide signaling pathway for potential pharmacological intervention in the treatment of breast cancer. Previously, we have shown that certain ceramide analogs have therapeutic potential in the treatment of chemo-sensitive and multidru

SUBMITTER: Goyal N 

PROVIDER: S-EPMC10399632 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature