Transcriptional signatures measured in whole blood correlate with protection against tuberculosis in inbred and outbred mice.

ABSTRACT: Although BCG has been used for almost 100 years to immunize against Mycobacterium tuberculosis, TB remains a global public health threat. Numerous clinical trials are underway studying novel vaccine candidates and strategies to improve or replace BCG, but vaccine development still lacks a well-defined set of immune correlates to predict vaccine-induced protection against tuberculosis. This study aimed to address this gap by examining transcriptional responses to BCG vaccination in C57BL/6 inbred mice, coupled with protection studies using Diversity Outbred mice. We evaluated relative gene expression in blood obtained from vaccinated mice, because blood is easily accessible, and data can be translated to human studies. We first determined that the average peak time after vaccination is 14 d

SUBMITTER: Kurtz SL 

PROVIDER: S-EPMC10399789 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature