Models of Purkinje cell dendritic tree selection during early cerebellar development.

ABSTRACT: We investigate the relationship between primary dendrite selection of Purkinje cells and migration of their presynaptic partner granule cells during early cerebellar development. During postnatal development, each Purkinje cell grows more than three dendritic trees, from which a primary tree is selected for development, whereas the others completely retract. Experimental studies suggest that this selection process is coordinated by physical and synaptic interactions with granule cells, which undergo a massive migration at the same time. However, technical limitations hinder continuous experimental observation of multiple cell populations. To explore possible mechanisms underlying this selection process, we constructed a computational model using a new computational framework, NeuroDevSim.

SUBMITTER: Kato M 

PROVIDER: S-EPMC10399850 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature