The safety and efficacy of remimazolam tosylate combined with propofol in upper gastrointestinal endoscopy: A multicenter, randomized clinical trial.

ABSTRACT:

Introduction

Hypotension is the most common adverse event under propofol-mediated sedation and is possible to cause varying degrees of damage to patients. Whereas remimazolam has a poorer sedative effect than propofol.

Aim

The aim of this study was to explore the advantages of the combination of remimazolam tosylate and propofol.

Methods

304 patients were divided into the remimazolam tosylate group (RT group), the propofol group (P group), and the remimazolam tosylate plus propofol group(R+T group). The primary outcome was the incidence of hypotension. Secondary outcomes included the results of sedation and recovery. The safety results mainly include the incidence of Hypotension, adverse respiratory events, postoperative nausea and vomiting, hiccup, cough, body moveme

SUBMITTER: Wei A 

PROVIDER: S-EPMC10399878 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature