Associations of functional human leucocyte antigen class I groups with HIV viral load in a heterogeneous cohort.

ABSTRACT:

Objective

Human leucocyte antigen (HLA) class I alleles are the main host genetic factors involved in controlling HIV-1 viral load (VL). Nevertheless, HLA diversity has proven a significant challenge in association studies. We assessed how accounting for binding affinities of HLA class I alleles to HIV-1 peptides facilitate association testing of HLA with HIV-1 VL in a heterogeneous cohort.

Design

Cohort from the Strategic Timing of AntiRetroviral Treatment (START) study.

Methods

We imputed HLA class I alleles from host genetic data (2546 HIV+ participants) and sampled immunopeptidomes from 2079 host-paired viral genomes (targeted amplicon sequencing). We predicted HLA class I binding affinities to HIV-1 and unspecific peptides, grouping alleles into functional cluste

SUBMITTER: Zucco AG 

PROVIDER: S-EPMC10399941 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature