The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis.

ABSTRACT:

Objectives

Disrupted auditory networks play an important role in the pathophysiology of psychosis, with abnormalities already observed in individuals at clinical high-risk for psychosis (CHR). Here, we examine structural and functional connectivity of an auditory network in CHR utilising state-of-the-art electroencephalography and diffusion imaging techniques.

Methods

Twenty-six CHR subjects and 13 healthy controls (HC) underwent diffusion MRI and electroencephalography while performing an auditory task. We investigated structural connectivity, measured as fractional anisotropy in the Arcuate Fasciculus (AF), Cingulum Bundle, and Superior Longitudinal Fasciculus-II. Gamma-band lagged-phase synchronisation, a functional connectivity measure, was calculated between cortical re

SUBMITTER: Langhein M 

PROVIDER: S-EPMC10399965 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature