DNA methylation signatures of duplicate gene evolution in angiosperms.

ABSTRACT: Gene duplication is a source of evolutionary novelty. DNA methylation may play a role in the evolution of duplicate genes (paralogs) through its association with gene expression. While this relationship has been examined to varying extents in a few individual species, the generalizability of these results at either a broad phylogenetic scale with species of differing duplication histories or across a population remains unknown. We applied a comparative epigenomic approach to 43 angiosperm species across the phylogeny and a population of 928 Arabidopsis (Arabidopsis thaliana) accessions, examining the association of DNA methylation with paralog evolution. Genic DNA methylation was differentially associated with duplication type, the age of duplication, sequence evolution, and gene expressio

SUBMITTER: Kenchanmane Raju SK 

PROVIDER: S-EPMC10400039 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature