A Graphical Overview of the Histopathology of Human Melioidosis: A Case Series.

ABSTRACT:

Background

Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, has a major global health impact and a wide range of different disease manifestations. Histopathological descriptions of melioidosis remain limited. Granulomatous inflammation with multinucleated giant cells are considered classic features. We aim to present a graphical overview of histopathological manifestations of melioidosis, serving as an aid in diagnosing this disease.

Methods

We performed a retrospective international multicenter laboratory-based analysis of formalin-fixed paraffin-embedded (FFPE) tissue from culture-confirmed melioidosis autopsy and biopsy cases. Available FFPE tissue was stained with hematoxylin and eosin and immunostainings including a monoclonal antibod

SUBMITTER: Savelkoel J 

PROVIDER: S-EPMC10400137 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature