Ontology highlight
ABSTRACT:
SUBMITTER: Olabode AS
PROVIDER: S-EPMC10400143 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Olabode Abayomi S AS Mumby Mitchell J MJ Wild Tristan A TA Muñoz-Baena Laura L Dikeakos Jimmy D JD Poon Art F Y AFY
Molecular biology and evolution 20230801 8
Nef is an accessory protein unique to the primate HIV-1, HIV-2, and SIV lentiviruses. During infection, Nef functions by interacting with multiple host proteins within infected cells to evade the immune response and enhance virion infectivity. Notably, Nef can counter immune regulators such as CD4 and MHC-I, as well as the SERINC5 restriction factor in infected cells. In this study, we generated a posterior sample of time-scaled phylogenies relating SIV and HIV Nef sequences, followed by reconst ...[more]